BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site
BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site
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DOI：
10.1111/j.1755-148x.2011.00837.x
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发表时间：
2011-04-01
影响因子：
4.3
通讯作者：
Bastian, Boris C.
中科院分区：
文献类型：
--
作者：
Bauer, Juergen;Buettner, Petra;Bastian, Boris C.
在皮肤黑色素瘤中，发生在轻度或中度阳光损伤部位的致癌性BRAF突变比发生在严重累积性太阳紫外线（UV）损伤部位的突变更常见。我们研究了来自不同环境紫外线辐射水平的地理区域的皮肤黑色素瘤，以描述累积紫外线损伤、年龄和解剖部位对BRAF突变频率的相对影响。我们发现，BRAF突变的黑色素瘤发生在一个年轻的年龄组的皮肤上没有明显的日光弹性组织变性，并不经常影响头部和颈部地区，相比没有BRAF突变的黑色素瘤。研究结果表明，BRAF突变的黑色素瘤在生命早期出现在低累积紫外线剂量下，而没有BRAF突变的黑色素瘤需要随着时间的推移积累高紫外线剂量。解剖部位对突变谱的影响进一步表明皮肤黑素细胞之间的区域差异。
P>Oncogenic BRAF mutations are more frequent in cutaneous melanoma occurring at sites with little or moderate sun-induced damage than at sites with severe cumulative solar ultraviolet (UV) damage. We studied cutaneous melanomas from geographic regions with different levels of ambient UV radiation to delineate the relative effects of cumulative UV damage, age, and anatomic site on the frequency of BRAF mutations. We show that BRAF-mutated melanomas occur in a younger age group on skin without marked solar elastosis and less frequently affect the head and neck area, compared to melanomas without BRAF mutations. The findings indicate that BRAF-mutated melanomas arise early in life at low cumulative UV doses, whereas melanomas without BRAF mutations require accumulation of high UV doses over time. The effect of anatomic site on the mutation spectrum further suggests regional differences among cutaneous melanocytes.