The Possibility of Suppression of Increased Postprandial Blood Glucose Levels by Gamma-Polyglutamic Acid-Rich Natto in the Early Phase after Eating: A Randomized Crossover Pilot Study
The Possibility of Suppression of Increased Postprandial Blood Glucose Levels by Gamma-Polyglutamic Acid-Rich Natto in the Early Phase after Eating: A Randomized Crossover Pilot Study
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DOI：
10.3390/nu12040915
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发表时间：
2020-04-01
期刊：
影响因子：
5.9
通讯作者：
Hashimoto, Koichi
中科院分区：
文献类型：
--
作者：
Araki, Risa;Fujie, Keiko;Hashimoto, Koichi
最近开发了含有高水平的γ-聚谷氨酸（γ-PGA）的纳豆。我们研究了食用富含γ-PGA的纳豆对人类餐后血糖波动的影响。在20 - 64岁的健康志愿者中进行随机交叉膳食试验研究，使用以下试验膳食：（1）白色米饭（WR），（2）低γ-PGA纳豆粉（WR+低γ-PGA纳豆），和（3）高γ-PGA纳豆粉（WR+高γ-PGA纳豆）。在每次访视前和负荷后120分钟采集血样。计算并比较测试膳食中血糖和胰岛素水平的增量曲线下面积（IAUC）。在0 - 120分钟时，高-和低-γ-PGA纳豆餐的血糖IAUC（主要终点）比WR低20.1%和15.4%，仅高-γ-PGA纳豆餐和WR之间存在显著差异（p <0.05）。在0 - 15、0 - 30和0 - 45分钟时，高-PGA纳豆餐的血糖IAUC低于低-γ-PGA纳豆餐（所有p <0.05）。高-PGA纳豆可能会抑制血糖升高的早期阶段后吃的可能性表明。
The natto containing high levels of gamma-polyglutamic acid (gamma -PGA) was recently developed. We investigated the effect of gamma -PGA-rich natto consumption on postprandial glycemic excursion in humans. A randomized crossover meal test study was performed on healthy volunteers aged 20-64 years using the following test meals: (1) white rice (WR), (2) low-gamma -PGA natto meal (WR + low-gamma -PGA natto), and (3) high-gamma -PGA natto meal (WR + high-gamma -PGA natto). Blood samples were obtained at each visit before and for 120 min after loading. The incremental area under the curve (IAUC) of blood glucose and insulin levels was calculated and compared among the test meals. The blood glucose's IAUC at 0-120 min, the primary endpoint, was 20.1% and 15.4% lower for the high- and low-gamma -PGA natto meal than for the WR, with a significant difference only between the high-gamma -PGA natto meal and WR (p < 0.05). The blood glucose's IAUC at 0-15, 0-30, and 0-45 min was lower for the high--PGA natto meal than for the low-gamma -PGA natto meal (all p < 0.05). The possibility that high--PGA natto might suppress blood glucose elevations in the early phase after eating is indicated.