Prospective Comparison of 18-FDG PET/CT and Whole-Body MRI with Diffusion-Weighted Imaging in the Evaluation of Treatment Response of Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplant.
Prospective Comparison of 18-FDG PET/CT and Whole-Body MRI with Diffusion-Weighted Imaging in the Evaluation of Treatment Response of Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplant.
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在评估符合自体干细胞移植的多个骨髓瘤患者的治疗反应时，将18-FDG PET/CT和全身MRI与扩散加权成像进行预期比较。
DOI：
10.3390/cancers13081938
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发表时间：
2021-04-16
期刊：
影响因子：
5.2
通讯作者：
Marit G
中科院分区：
文献类型：
--
作者：
Mesguich C;Latrabe V;Hulin C;Lascaux A;Bordenave L;Hindié E;Marit G
在过去的十年中，多发性骨髓瘤的成像随着现代成像技术的越来越多，例如18-FDG PET/CT和MRI都具有高度的敏感性可能有助于评估治疗反应，但是传统的MRI缺乏预后价值。全身扩散加权MRI在诱导化疗后多发性骨髓瘤的治疗反应和移植后32个患者的中位随访后，我们发现只有18-FDG PET/CT有明显的预后，在患者治疗的两个重要时间点上，对宠物/CT代谢对疾病活动的总体监测的反应可能是有价值的。
在评估多发性骨髓瘤（MM）患者的治疗反应中，比较了18-FDG PET/CT（FDG-PET）和全身MRI的预后值（FDG-PET）和全身MRI的预后值（WB-DW-MRI）对于新诊断的MM的ASCT，在诱导化疗和ASCT后，对基线的FDG-PET和WB-DW-MRI进行了如果在32个月的中位随访后，则认为阳性摄取量优于肝脏摄取结果，在3/25的诱导后检查是阳性的，在3/27的患者中，诱导后的检查呈阳性。患者分别是FDG-PET，诱导后或ASCT的阳性，与较短的PFS相关（诱导后：中位数PFS 19个月，与未达到ASCT：PFS中位数为18个月，而未达到对数级别P = 0.0005）。与WB-DW-MRI相比，用于新诊断的MM的治疗反应评估。
Over the past decade, the imaging of multiple myeloma has evolved with the increasing use of modern imaging techniques such as 18-FDG PET/CT and MRI. Both imaging modalities have high sensitivity for the detection of bone involvement. 18-FDG PET/CT may help assess treatment response, but conventional MRI lacks prognostic value. Diffusion-Weighted is a newer MRI technique that could improve the assessment of tumor response. The aim of this prospective study was to compare the prognostic value of 18-FDG PET/CT and whole-body diffusion-weighted MRI in the evaluation of the treatment response of multiple myeloma after induction chemotherapy and after transplant. After a median follow-up of 32 months in 30 patients, we found that only 18-FDG PET/CT had significant prognostic value at two important time points of patients’ treatment. Integrating PET/CT metabolic response to the overall monitoring of disease activity might be of value in further improving patient’s management in multiple myeloma. To compare the prognostic values of 18-FDG PET/CT (FDG-PET) and Whole-Body MRI with Diffusion-Weighted Imaging (WB-DW-MRI) in the evaluation of treatment response of Multiple Myeloma (MM) patients eligible for ASCT. Thirty patients with newly diagnosed MM prospectively underwent FDG-PET and WB-DW-MRI at baseline, after induction chemotherapy and after ASCT. Response on WB-DW-MRI was evaluated with the MY-RADS criteria. FDG-PET was considered positive if residual uptake was superior to liver uptake. Imaging results were not used for treatment modification. The impact of imaging results on PFS was analyzed. After a median follow-up of 32 months, 10 patients relapsed. With WB-DW-MRI, post-induction examination was positive in 3/25 and post-ASCT examination was positive in 3/27 patients. However, neither study showed prognostic impact on PFS. FDG-PET was positive in 5/22 post-induction and 3/26 patients post-ASCT, respectively. Positivity of FDG-PET, post-induction or post-ASCT, was associated with a shorter PFS (post-induction: median PFS 19 months vs. not reached, log-rank p = 0.0089; post-ASCT: median PFS 18 months vs. not reached, log-rank p = 0.0005). Preliminary results from this small, single-center, prospective study show that, whether performed post-induction or post-ASCT, FDG-PET has a higher prognostic value than WB-DW-MRI for treatment response evaluation of newly diagnosed MM.
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DOI：
10.3324/haematol.2012.065698
发表时间：
2012-11-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Usmani, Saad Z.;Heuck, Christoph;Barlogie, Bart
通讯作者：
Barlogie, Bart
影响因子：
3.5
作者：
Mesguich, Charles;Hulin, Cyrille;Marit, Gerald
通讯作者：
Marit, Gerald
影响因子：
45.3
作者：
Zamagni, Elena;Nanni, Cristina;Kraeber-Bodere, Francoise
通讯作者：
Kraeber-Bodere, Francoise
影响因子：
19.7
作者：
Giles, Sharon L.;Messiou, Christina;deSouza, Nandita M.
通讯作者：
deSouza, Nandita M.
影响因子：
2.6
作者：
Lacognata, C.;Crimi, F.;Zambello, R.
通讯作者：
Zambello, R.