Promiscuity and the single receptor: NKG2D
Promiscuity and the single receptor: NKG2D
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DOI：
10.1038/nri2144
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发表时间：
2007-09-01
影响因子：
100.3
通讯作者：
Trowsdale, John
中科院分区：
文献类型：
--
作者：
Eagle, Robert A.;Trowsdale, John
NKG 2D（自然杀伤组2，成员D）是一种由自然杀伤（NK）细胞和T细胞表达的强大活化受体，可调节感染，癌症和自身免疫期间的免疫反应。NKG 2D配体包含一系列不同的MHC- I类相关蛋白，这些蛋白可通过细胞应激上调。为什么同一个受体有这么多的配体对宿主是有益的？在这篇观点文章中，我们提出，尽管与病毒的竞争是这种多样性最有可能的进化驱动力，但可能还有其他解释。
NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by natural killer (NK) cells and T cells that regulates immune responses during infection, cancer and autoimmunity. NKG2D ligands comprise a diverse array of MHC-class- I- related proteins that are upregulated by cellular stress. Why is it beneficial for the host to have so many ligands for the same receptor? In this Opinion article, we propose that although competition with viruses is the most likely evolutionary drive for this diversity, there might be other explanations.