Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression
Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression
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DOI：
10.1176/appi.ajp.162.10.1980
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发表时间：
2005-10-01
影响因子：
17.7
通讯作者：
Goodwin, GM
中科院分区：
文献类型：
--
作者：
Clark, L;Sarna, A;Goodwin, GM
目的：作者的目的是表征双相情感障碍患者亲属的认知灵活性和语言学习，以及常郁患者复发性重度抑郁症。方法：对27例ⅰ型双相情感障碍先显者一级亲属、15例复发性单相抑郁症门诊优生患者和47例健康对照者进行维度内/维度外转换任务和加州语言学习测验。结果：双相I型障碍患者和心境良好的单相抑郁症患者的亲属在维度内/维度外转换任务中的失败率高于健康对照者。在外维度转移阶段的损伤是明显的。语言学习、延迟回忆和认知在所有组中均未受损。结论：注意力集中转移可能代表心境障碍的一种内表型，与潜在的易感性有关，而不是实际的疾病表型。
Objective: The authors' goal was to characterize cognitive flexibility and verbal learning in relatives of patients with bipolar disorder and in euthymic patients with recurrent major depression.Method: The intradimensional/extradimensional shift task and California Verbal Learning Test were administered to 27 first-degree relatives of probands with bipolar I disorder, 15 euthymic outpatients with recurrent unipolar depression, and 47 healthy comparison subjects.Results: The relatives of patients with bipolar I disorder and the euthymic patients with unipolar depression were more likely to fail the intradimensional/extradimensional shift task than the healthy comparison subjects. The impairments at the extradimensional shift stage were pronounced. Verbal learning, delayed recall, and recognition were unimpaired in all groups.Conclusions: Attentional set shifting may represent an endophenotype in mood disorder, related to underlying vulnerability rather than the actual disease phenotype.