Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers.
Effect of intravenous fructose on the P-31 MR spectrum of the liver: dose response in healthy volunteers.
复制标题
静脉注射果糖对肝脏 P-31 MR 谱的影响：健康志愿者的剂量反应。
作者：
F. Terrier;P. Vock;J. Cotting;R. Ladebeck;J. Reichen;D. Hentschel
动态磷-31磁共振（MR）光谱的肝脏后静脉注射果糖已被建议作为肝功能的测试。为了建立正常人类肝脏中磷代谢物的剂量-反应曲线，四名健康志愿者分别在不同的日子里给予两到四种不同的果糖剂量：每公斤体重62.5、125、250、375或500毫克。在给予果糖前后，以2.5分钟的间隔，在至少30分钟内，用2-T全身磁仪获得肝脏的P-31磁共振光谱。果糖负荷引起了显著的、线性剂量依赖性的磷酸单酯积累（r = 0.72, P < 0.05）。无机磷酸盐含量降低（r = 0.78, P < 0.01）。005)和三磷酸腺苷（r = 0.73, P < 0.01）。在这些实验的基础上，动态P-31磁共振光谱在肝功能评估中似乎很有前景。
Dynamic phosphorus-31 magnetic resonance (MR) spectroscopy of the liver after intravenous administration of fructose has been suggested as a test of liver function. To establish dose-response curves of the phosphorus metabolites in the normal human liver, each of four healthy volunteers was given two to four different fructose doses on separate days: 62.5, 125, 250, 375, or 500 mg per kilogram of body weight. P-31 MR spectra of the liver were acquired with a 2-T whole-body magnetic, both before and after fructose administration, at 2.5-minute intervals over at least 30 minutes. The fructose load caused a significant, linearly dose-dependent accumulation of phosphomonoesters (r = .72, P less than .01) and a decrease in inorganic phosphate (r = .78, P less than .005) and adenosine triphosphate (r = .73, P less than .01). On the basis of these experiments, dynamic P-31 MR spectroscopy seems promising in the assessment of liver function.