Heritable component for external apical root resorption in patients treated orthodontically
Heritable component for external apical root resorption in patients treated orthodontically
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DOI：
10.1016/s0889-5406(97)70189-6
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发表时间：
1997-03-01
影响因子：
3
通讯作者：
Tolley, EA
中科院分区：
文献类型：
--
作者：
Harris, EF;Kineret, SE;Tolley, EA
外根尖吸收（EARR）是正畸患者中常见且偶尔严重的问题。机械力压缩牙周组织，导致牙骨质局部吸收，使牙本质因弹性活动而受到破坏。控制 EARR 发生和程度的因素知之甚少，但可能存在家族（遗传）因素导致易感性。我们对全兄弟姐妹（103 对）进行了研究，所有这些人都由一名正牙医生使用相同的技术进行治疗。在治疗前后通过头颅照片和全景片测量牙冠和牙根的长度。对每位患者的六个根进行评分，根长度的减少是因变量。使用广义线性模型量化同胞内部和同胞之间的方差，同时控制性别、年龄和咬合不正的严重程度（FMA、ANB、AOBO、overjet、NAP）作为协变量。结果显示，同胞之间的方差显着大于同胞内部的方差，这意味着 EARR 易感性存在实质性的遗传因素。遗传力估计相当高，三个牙根平均为 70%，尽管下颌切牙的遗传力较低，可能是因为变异很小，没有发现易感性存在性别或年龄差异的证据，可传播成分的量化表明寻找控制易感性家族差异的生化因素将是有用的。
External apical root resorption (EARR) is a common and occasionally critical problem in orthodontic patients. Mechanical forces compress the periodontium, leading to localized resorption of cementum that exposes dentin to destruction by elastic activity. Factors controlling occurrence and extent of EARR are poorly understood, but there may be a familial (genetic) factor in susceptibility, A sample of full siblings (103 pairs) was studied, all of whom were treated with the same technique by one orthodontist. Crown and root lengths were measured on cephalograms and panoral films before and after treatment. Six roots were scored on each patient, and decrease in root length was the dependent variable. Generalized linear models were used to quantify within and among sibship variances while controlling for sex, age, and severity of malocclusion (FMA, ANB, AOBO, overjet, NAP) as covariates, Results showed significantly greater among-than within-sibship variances, meaning there is a substantive genetic factor in susceptibility to EARR. Heritability estimates were fairly high, averaging 70% for three roots, although low for the mandibular incisor, probably because of little variation, No evidence was found for a sex or age difference in susceptibility, Quantification of a transmissible component suggests it would be useful to search for the biochemical factors controlling the familial differences in susceptibility.