NUCLEOTIDE SUBSTITUTION AT MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II LOCI - EVIDENCE FOR OVERDOMINANT SELECTION
NUCLEOTIDE SUBSTITUTION AT MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II LOCI - EVIDENCE FOR OVERDOMINANT SELECTION
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DOI：
10.1073/pnas.86.3.958
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发表时间：
1989-02-01
影响因子：
11.1
通讯作者：
NEI, M
中科院分区：
文献类型：
--
作者：
HUGHES, AL;NEI, M
To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous (amino acid-altering) nucleotide substitutions in the putative antigen-recognition site (included in the first domain of the MHC molecule) and other regions of human and mouse class II genes were examined. In the putative antigen-recognition site, the rate of nonsynonymous substitution was found to exceed that of synonymous substitution, whereas in the second domain the former was significantly lower than the latter. In light of a previous theoretical study and parallel findings in class I MHC loci, we conclude that the unusually high degree of polymorphism at class II MHC loci is caused mainly by overdominant selection (heterozygote advantage) operating in the antigen-recognition site.
