Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures
Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures
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DOI：
10.1016/j.str.2019.11.002
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发表时间：
2019-12-03
期刊：
影响因子：
5.7
通讯作者：
Sali, Andrej
中科院分区：
文献类型：
--
作者：
Berman, Helen M.;Adams, Paul D.;Sali, Andrej
生物分子系统的结构越来越多地通过集成建模来计算。在这种方法中，结构模型是通过结合来自多个来源的信息，包括不同的实验方法和先验模型。2019年，作为生物物理学会卫星会议举行了一次研讨会，以评估进展并讨论存档综合结构的进一步要求。讲习班的主要目标是建立共识，以应对在创建共同数据标准、建立联合数据交换方法和开发验证综合结构的机制方面所涉及的挑战。研讨会的摘要和提出的建议载于此处。
Structures of biomolecular systems are increasingly computed by integrative modeling. In this approach, a structural model is constructed by combining information from multiple sources, including varied experimental methods and prior models. In 2019, a Workshop was held as a Biophysical Society Satellite Meeting to assess progress and discuss further requirements for archiving integrative structures. The primary goal of the Workshop was to build consensus for addressing the challenges involved in creating common data standards, building methods for federated data exchange, and developing mechanisms for validating integrative structures. The summary of the Workshop and the recommendations that emerged are presented here.