Acute cocaine administration depresses cortical activity.
Acute cocaine administration depresses cortical activity.
复制标题
急性可卡因给药会抑制皮质活动。
DOI：
10.1038/sj.npp.1300482
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Lavin,Antonieta
中科院分区：
文献类型：
--
作者：
Trantham-Davidson,Heather;Lavin,Antonieta
Psychostimulants, when administered acutely, produce significant deficits in cognitive tasks. Indeed, there is considerable evidence that acute administration of cocaine alters cellular processes at the level of the nucleus accumbens and the ventral tegmental area (VTA). However, there have been few studies that explore the acute effects of cocaine in the prefrontal cortex (PFC). Here we report that acute cocaine administration in vivo evokes a prolonged membrane depolarization, decreases cortical spontaneous firing, compromises spontaneous membrane bistability, and blunts the VTA-evoked responses in the PFC. Moreover, acute cocaine administration decreases the amplitude of the EPSP-IPSP sequence that precedes the initiation of the Up states in the PFC, therefore compromising the driving force of cortical bistability and thereby cortical excitability.
