Human epididymis protein 4 reference limits and natural variation in a Nordic reference population.
Human epididymis protein 4 reference limits and natural variation in a Nordic reference population.
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DOI：
10.1007/s13277-011-0256-4
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Bjerner, Johan
中科院分区：
文献类型：
--
作者：
Bolstad, Nils;Oijordsbakken, Miriam;Nustad, Kjell;Bjerner, Johan
本研究的目的是建立人附睾蛋白4（HE 4）的参考限值，并研究影响健康受试者中HE 4水平的因素。在北欧参考区间项目生物库和数据库生物库的1，591个样本中测量了HE 4，其中802个样本使用手动HE 4 EIA（Fujirebio），792个样本使用Architect HE 4（Abbott）。使用统计软件R计算参考限。使用多变量模型研究供体特征如年龄、性别、体重指数、吸烟习惯和肌酐对HE 4水平的影响。研究表明，年龄是健康受试者中HE 4的主要决定因素，30岁时HE 4水平比20岁时高2%，40岁时高9%，50岁时高20%，60岁时高37%，70岁时高63%，80岁时高101%。吸烟者的HE 4水平比不吸烟者高29%。总之，健康受试者的HE 4水平与年龄和吸烟状况有关。建议了依赖于温度的参考限值。本文的在线版本（doi：10.1007/s13277-011-0256-4）包含补充材料，可供授权用户使用。
The objectives of this study are to establish reference limits for human epididymis protein 4, HE4, and investigate factors influencing HE4 levels in healthy subjects. HE4 was measured in 1,591 samples from the Nordic Reference Interval Project Bio-bank and Database biobank, using the manual HE4 EIA (Fujirebio) for 802 samples and the Architect HE4 (Abbott) for 792 samples. Reference limits were calculated using the statistical software R. The influence of donor characteristics such as age, sex, body mass index, smoking habits, and creatinine on HE4 levels was investigated using a multivariate model. The study showed that age is the main determinant of HE4 in healthy subjects, corresponding to 2% higher HE4 levels at 30 years (compared to 20 years), 9% at 40 years, 20% at 50 years, 37% at 60 years, 63% at 70 years, and 101% at 80 years. HE4 levels are 29% higher in smokers than in nonsmokers. In conclusion, HE4 levels in healthy subjects are associated with age and smoking status. Age-dependent reference limits are suggested. The online version of this article (doi:10.1007/s13277-011-0256-4) contains supplementary material, which is available to authorized users.
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