Rotary and linear molecular motors driven by pulses of a chemical fuel
Rotary and linear molecular motors driven by pulses of a chemical fuel
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DOI：
10.1126/science.aao1377
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发表时间：
2017-10-20
期刊：
影响因子：
56.9
通讯作者：
Wilson, Miriam R.
中科院分区：
文献类型：
--
作者：
Erbas-Cakmak, Sundus;Fielden, Stephen D. P.;Wilson, Miriam R.
许多生物分子马达催化化学燃料的水解，如三磷酸腺苷，并利用释放的能量通过信息棘轮机制引导运动。在这里，我们描述了化学驱动的人造旋转式和线性分子马达，它们通过一种根本不同类型的机制运行。[2]和[3]链烷旋转分子马达的定向旋转和线性分子泵使底物远离平衡的输送是由酸碱振荡引起的。这些变化同时切换了结合部位的亲和力和赛道上障碍物的不稳定性，创造了一个能量棘轮。直线分子马达和旋转式分子马达由一等份的化学燃料三氯乙酸驱动。一个燃料脉冲产生360度单向旋转高达87%的冠醚在[2]环戊二烯旋转马达。
Many biomolecular motors catalyze the hydrolysis of chemical fuels, such as adenosine triphosphate, and use the energy released to direct motion through information ratchet mechanisms. Here we describe chemically-driven artificial rotary and linear molecular motors that operate through a fundamentally different type of mechanism. The directional rotation of [2]- and [3] catenane rotary molecular motors and the transport of substrates away from equilibrium by a linear molecular pump are induced by acid-base oscillations. The changes simultaneously switch the binding site affinities and the labilities of barriers on the track, creating an energy ratchet. The linear and rotary molecular motors are driven by aliquots of a chemical fuel, trichloroacetic acid. A single fuel pulse generates 360 degrees unidirectional rotation of up to 87% of crown ethers in a [2] catenane rotary motor.