Inappropriate antidiuresis and carcinoma of the lung: detection of arginine vasopressin in tumor extracts by immunoassay.
Inappropriate antidiuresis and carcinoma of the lung: detection of arginine vasopressin in tumor extracts by immunoassay.
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不适当的抗利尿和肺癌：通过免疫分析检测肿瘤提取物中的精氨酸加压素。
DOI：
10.1210/jcem-26-9-970
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发表时间：
1966
期刊：
影响因子：
--
通讯作者：
Robert D. Utiger
中科院分区：
文献类型：
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作者：
Robert D. Utiger
本文报告一例未分化(燕麦细胞)肺癌合并低钠血症、尿钠排泄及尿液高渗向血浆排泄的病例。电解质和渗透压异常通过限水得到纠正，全肺切除术后未复发。通过放射免疫分析，发现肿瘤提取物中含有精氨酸加压素(或一些与之密切相关的肽)，含量范围为8~427μU/mg湿组织重量。从未受影响的肺、淋巴结和无此综合征患者的肺肿瘤中提取的提取物没有检测到活性。在尸检中获得的脑垂体腺含有的数量要多得多。这些研究进一步证明，与各种恶性肿瘤相关的抗利尿激素分泌不当综合征是由于肿瘤产生的激素所致。
A case is described in which an undifferentiated (oat cell) carcinoma of the lung was associated with hyponatremia, natruresis and excretion of urine hypertonic to plasma. The electrolyte and osmolality abnormalities were corrected by water restriction and did not recur after pneumonectomy. By means of radioimmunoassay, extracts of the tumor were found to contain arginine vasopressin (or some very closely related pep tide) in amounts ranging from 8 to 427 μU/mg wet tissue weight. Extracts from uninvolved lung, lymph node, and from lung tumors of patients without this syndrome contained no detectable activity. Pituitary glands obtained at autopsy contained vastly greater quantities. These studies provide further evidence that the syndrome of inappropriate secretion of antidiuretic hormone associated with various malignant tumors is due to hormone production by the tumor.