Human chorionic gonadotropin/luteinizing hormone receptor expression in the adult rat spinal cord.
Human chorionic gonadotropin/luteinizing hormone receptor expression in the adult rat spinal cord.
复制标题
成年大鼠脊髓中人绒毛膜促性腺激素/黄体生成素受体的表达。
DOI：
10.1016/s0304-3940(02)01157-6
复制
发表时间：
2003
影响因子：
2.5
通讯作者：
Magnuson,DavidSK
中科院分区：
文献类型：
--
作者：
Rao,SatishC;Li,Xian;Rao,ChV;Magnuson,DavidSK
成年和胎鼠脑中含有人绒毛膜促性腺激素/促黄体激素（hCG/LH）受体，其功能是介导促性腺激素的神经营养、神经内分泌和行为作用。我们假设脊髓也含有这些受体。我们现在已经证明了原位杂交，免疫组织化学，局部放射自显影，成年大鼠脊髓表达hCG/LH受体。阳性细胞包括中间灰质和腹侧灰质中的运动神经元、中间神经元和/或胶质细胞，背侧灰质中的中间神经元和/或胶质细胞，以及白色物质中的少突胶质细胞或星形胶质细胞。受体能够结合适当的配体125 I-hCG。这些受体在脊髓中的功能意义尚不清楚，但我们可以推测它们可能具有神经营养功能。
The adult and fetal rat brain contains human chorionic gonadotropin/luteinizing hormone (hCG/LH) receptors, that are functional in mediating the neurotropic, neuroendocrine and behavioral actions of gonadotropins. We hypothesized that the spinal cord also contains these receptors. We have now demonstrated by in situ hybridization, immunohistochemistry, and topical autoradiography that the adult rat spinal cord expresses hCG/LH receptors. Positive cells included motoneurons, interneurons and/or glia in the intermediate and ventral gray matter, interneurons and/or glia in the dorsal gray matter, and oligodendrocytes or astrocytes in the white matter. The receptors were able to bind an appropriate ligand,125I-hCG. The functional significance of these receptors in the spinal cord is unknown, but we can speculate that they may be neurotrophic in function.