Understanding crypticity is the key to revealing the pathogenesis of autoimmunity.
Understanding crypticity is the key to revealing the pathogenesis of autoimmunity.
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了解其神秘性是揭示自身免疫发病机制的关键。
DOI：
10.1016/j.it.2005.05.007
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Sercarz,EliE
中科院分区：
文献类型：
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作者：
Moudgil,KamalD;Sercarz,EliE
在这种情况下，我们认为，自身抗原内的抗原决定簇的层次结构是在塑造潜在的自身反应性T细胞库的主要影响。良好的加工和呈现的决定因素构成了“主导自我”，而加工和/或呈现不良的决定因素对T细胞是不可见的，并构成了“神秘的自我”，我们认为这是自身免疫理论的基本基石。它解释了大量的自反应克隆，因为在胸腺中建立了类似的层次结构，并控制着阳性和阴性选择。此外，这种主要针对隐蔽决定簇的残留T细胞库将包含一些对MHC和抗原具有足够亲和力的T细胞，使它们能够在炎症条件下应答，从而促进先前隐蔽决定簇的呈递。
In this opinion, we propose that the hierarchy of antigenic determinants within self-antigens is the major influence in molding the potentially autoreactive T-cell repertoire. The well processed and presented determinants constitute a ‘dominant self', whereas the poorly processed and/or presented determinants will be invisible to T cells and comprise a ‘cryptic self', which we consider a fundamental cornerstone of a theory of autoimmunity. It accounts for the large repertoire of self-reactive clones because a similar hierarchy is established in the thymus and controls positive and negative selection. Furthermore, this residual T-cell repertoire, largely directed against cryptic determinants, will contain some T cells with sufficient affinity for MHC and antigen that enables them to respond under inflammatory conditions, thus facilitating presentation of previously cryptic determinants.