Lethality and centrality in protein networks
Lethality and centrality in protein networks
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DOI：
10.1038/35075138
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发表时间：
2001-05-03
期刊：
影响因子：
64.8
通讯作者：
Oltvai, ZN
中科院分区：
文献类型：
--
作者：
Jeong, H;Mason, SP;Oltvai, ZN
传统上，蛋白质是根据它们作为催化剂、信号分子或细胞和微生物中的积木的个别作用来确定的。但我们的后基因组观点正在将蛋白质的作用扩大到蛋白质-蛋白质相互作用网络中的一个元素，在这个网络中，它在功能模块中具有上下文或细胞功能。在这里，我们通过证明酿酒酵母中单个基因缺失的表型结果在很大程度上受到其蛋白质产物在复杂的分子相互作用层级网络中的拓扑位置的影响，从而为这一观点提供了定量支持。
Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling molecules, or building blocks in cells and microorganisms. But our post-genomic view is expanding the protein's role into an element in a network of protein–protein interactions as well, in which it has a contextual or cellular function within functional modules,. Here we provide quantitative support for this idea by demonstrating that the phenotypic consequence of a single gene deletion in the yeastSaccharomyces cerevisiaeis affected to a large extent by the topological position of its protein product in the complex hierarchical web of molecular interactions.