Coffee consumption is associated with DNA methylation levels of human blood
Coffee consumption is associated with DNA methylation levels of human blood
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DOI：
10.1038/ejhg.2016.175
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发表时间：
2017-05-01
影响因子：
5.2
通讯作者：
Ritz, Beate
中科院分区：
文献类型：
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作者：
Chuang, Yu-Hsuan;Quach, Austin;Ritz, Beate
咖啡的有益健康效应已经被归因于饮用咖啡，但尚不清楚表观遗传学是否可能在这一过程中发挥作用。在这里，我们将表观基因组范围的DNA甲基化水平与习惯性咖啡消费联系起来，这是来自两项研究(2100名和215名参与者)和一项唾液样本(256名参与者)。调整了年龄、性别和血细胞组成，有一个CpG(接近ALPPL2的cg21566642)超过了全基因组意义(P=3.7x10(-10))，在其他10个CpG中达到显著水平。
Beneficial health effects have been attributed to coffee consumption, but it is not yet known whether epigenetics may have a role in this process. Here we associate epigenome-wide DNA methylation levels to habitual coffee consumption from two studies with blood (2100 and 215 participants), and one with saliva samples (256 participants). Adjusting for age, gender, and blood cell composition, one CpG (cg21566642 near ALPPL2) surpassed genome-wide significance (P= 3.7 x 10(-10)) and from among 10 additional CpGs significant at P