Correlated bursts of activity in the neonatal hippocampus in vivo
Correlated bursts of activity in the neonatal hippocampus in vivo
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DOI：
10.1126/science.1071111
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发表时间：
2002-06-14
期刊：
影响因子：
56.9
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Leinekugel, X;Khazipov, R;Buzsáki, G
体内未成熟皮质网络的行为在很大程度上仍然未知。使用多位点细胞外和膜片钳记录，我们观察到持续0.5至3秒的同步神经元活动的复发性突发自发地发生在自由移动和麻醉的大鼠幼崽的海马。缓慢的节奏（0.33和0.1赫兹）的影响和贡献的γ-氨基丁酸A介导的和谷氨酸受体介导的突触信号在海马爆发的产生让人想起巨大的去极化电位在体外观察。这种最早的模式，在出生后第二周多样化，可以为未成熟的神经元提供相关的活动，并可能成为海马网络活动依赖性成熟的基础。
The behavior of immature cortical networks in vivo remains largely unknown. Using multisite extracellular and patch-clamp recordings, we observed recurrent bursts of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred spontaneously in the hippocampus of freely moving and anesthetized rat pups. The influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both gamma-aminobutyric acid A-mediated and glutamate receptor-mediated synaptic signals in the generation of hippocampal bursts was reminiscent of giant depolarizing potentials observed in vitro. This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network.