Tetraazacalix[2]arence[2]triazine Coated Fe3O4/SiO2 Magnetic Nanoparticles for Simultaneous Dispersive Solid Phase Extraction and Determination of Trace Multitarget Analytes
Tetraazacalix[2]arence[2]triazine Coated Fe3O4/SiO2 Magnetic Nanoparticles for Simultaneous Dispersive Solid Phase Extraction and Determination of Trace Multitarget Analytes
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Tetraazacalix[2]arence[2]triazine 涂层 Fe3O4/SiO2 磁性纳米颗粒用于同时分散固相萃取和痕量多目标分析物测定
DOI：
10.1021/acs.analchem.6b02583
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发表时间：
2016
影响因子：
7.4
通讯作者：
Zhang Shusheng
中科院分区：
文献类型：
--
作者：
Zhang Wenfen;Zhang Yanhao;Jiang Qiong;Zhao Wenjie;Yu Ajuan;Chang Hong;Lu Ximei;Xie Fuwei;Ye Baoxian;Zhang Shusheng
为了满足多种多目标分析物同时提取和表征的需要，本文介绍了一种新型的四氮杂杯[2]芳烃[2]三嗪(TCT)包覆磁性纳米粒子(TCT MNP)的制备、表征及其应用。TCT组装了两个苯环和两个含氮交叉桥联的三氮杂环，表现出独特的结构框架和基于多个识别位点的多功能识别特征。其中包括π电子堆积、电荷转移、氢键和离子交换。TCT MNPs是一种分散的固相萃取吸附剂，对多环芳烃(PAHs)、硝基芳香族化合物和重金属离子具有很强的相互作用和吸附作用。设计并优化了分散磁性纳米颗粒固相萃取(d-MNSPE)和同时萃取分步洗脱(SESE)方法，对水样中的5种多环芳烃(菲、苯并(A)芘)、6种硝基芳香族化合物(4-硝基甲苯、2，4-二硝基甲苯、2，4，6-三硝基甲苯、4-硝基苯酚、2，4，6-三硝基苯酚)和4种金属离子(铜、锌、锰、镉)进行了分析。由于TCT MNPs的高稳定性、良好的耐久性、较大的饱和磁化强度、可重复使用和明显的富集性，采用SESE策略的d-MNSPE方法具有高的回收率(>；90%)和良好的精密度(相对标准偏差，RSD；10%)。用d-MNSPE富集后，结合常用的高效液相-荧光检测法、高效液相-紫外检测法和原子吸收光谱法，对自来水、河水和湖水中的多环芳烃、硝基芳香族化合物和金属离子进行了测定，检出限分别为0.09-0.15pgmL-1、6-11pgmL-1和17-53pgmL-1。用该方法成功地测定了吸烟者和非吸烟者尿样中的痕量多环芳烃，表明多功能的TCT MNPs和Robust方法在体液和疾病标志物的分析中具有重要的潜在应用价值。这种准确定量水中痕量组分的方法非常有价值，因为它们满足了环境和药物化学中尚未得到满足的需求。
To satisfy the requirement of simultaneous extraction and characterization of diverse kinds of multitarget analytes, the preparation, characterization, and application of a novel tetraazacalix[2]arene[2]triazine (TCT) coated magnetic nanoparticle (TCT MNP) adsorbent are presented in this paper. TCT assembles two benzene rings and two triazines with nitrogen cross-bridging links, which exhibits a unique structural framework and versatile recognition features based on the multiple recognition sites. These include π electron stacking, charge transfer, hydrogen bonding, and ion-exchange. TCT MNPs acted as a dispersive SPE adsorbent showing strong interaction with and adsorption of polycyclic aromatic hydrocarbons (PAHs), nitroaromatics, and heavy metal ions. The dispersive magnetic nanoparticle solid phase extraction (d-MNSPE) strategy with the simultaneous extraction and stepwise elution (SESE) procedure was designed and optimized for the five PAHs (phenanthrene, anthracene, pyrene, chrysene, and benzo(a)pyrene), six nitroaromatics (4-nitrotoluene, 2,4-dinitrotoluene, 2,4,6-trinitrotoluene, 4-nitrophenol, 2,4-dinitrophenol, and 2,4,6-trinitrophenol), and four metal ions (Cu, Zn, Mn, Cd) in aqueous samples. Due to the high stability, desirable durability, larger saturation magnetization, reuse and distinct enrichment capacity of TCT MNPs, the d-MNSPE method with the SESE strategy provided high recovery (>90%) and good precision (relative standard deviations, RSD < 10%). Coupled with the commonly used HPLC-fluorescence detection, HPLC-UV detection, and atomic absorption spectrometry, these trace probes in tap water, river water, and lake water were determined with very low detection limits, in the range of 0.09–0.15 pg mL–1for PAHs, 6–11 pg mL–1for nitroaromatics, and 17–53 pg mL–1for metal ions after being enriched by the d-MNSPE. The determination of trace PAHs in urine samples from smokers and nonsmokers was successfully carried out with this method, which implied that the versatile TCT MNPs and the robust method together represent a significant potential application in the analysis of body fluids and disease markers. Such methods for accurate quantification of trace components in water are very valuable as they fulfill an unmet need in environmental and medicinal chemistry.