THE EFFECTS OF IVERMECTIN ON TRANSMISSION OF ONCHOCERCA-VOLVULUS
THE EFFECTS OF IVERMECTIN ON TRANSMISSION OF ONCHOCERCA-VOLVULUS
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DOI：
10.1126/science.3753801
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发表时间：
1986-02-14
期刊：
影响因子：
56.9
通讯作者：
GREENE, BM
中科院分区：
文献类型：
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作者：
CUPP, EW;BERNARDO, MJ;GREENE, BM
单次口服剂量为每公斤体重200微克的伊维菌素可显著减少Simuelyahense对盘尾丝虫微丝蚴的摄取，Simuelyahense是西非热带雨林中一种有效的寄生虫黑蝇媒介。治疗三个月后，服用伊维菌素的患者感染苍蝇的比率明显低于服用乙胺嗪或安慰剂的患者，从而减少了病媒种群中发育中幼虫的数量。这种降低的传染率在治疗后6个月也很明显。这些结果有力地表明，伊维菌素可以有效地中断盘尾丝虫扭转的传播流行病学上的重要时期。
Ivermectin, given to onchocerciasis patients as a single oral dose of 200 micrograms per kilogram of body weight, substantially reduced the uptake of Onchocerca volvulus microfilariae by Simulium yahense, an efficient black fly vector of the parasite in the tropical rain forests of West Africa. Three months after treatment, patients given ivermectin infected flies at a significantly lower rate than those who had received diethylcarbamazine or placebo, thereby reducing the number of developing larvae in the vector population. This diminished rate of infectiousness was also evident 6 months after treatment. These results strongly suggest that ivermectin could be effective in interrupting transmission of Onchocerca volvulus for epidemiologically important periods of time.