Association of Major Depressive Disorder with remotely administered measures of cognition and subjective report of cognitive difficulties across the adult age spectrum.
Association of Major Depressive Disorder with remotely administered measures of cognition and subjective report of cognitive difficulties across the adult age spectrum.
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DOI：
10.1016/j.jad.2022.12.045
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发表时间：
2022-12
影响因子：
6.6
通讯作者：
R. S. Mackin;Chengshi Jin;Emily Burns;M. Kassel;E. Rhodes;R. Nosheny;M. Ashford;T. Banh;J. Eichenbaum;Kristen Knight;Rachana Tank;M. Camacho;J. Fockler;D. Truran;J. Neuhaus;M. Weiner
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文献类型：
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作者：
R. S. Mackin;Chengshi Jin;Emily Burns;M. Kassel;E. Rhodes;R. Nosheny;M. Ashford;T. Banh;J. Eichenbaum;Kristen Knight;Rachana Tank;M. Camacho;J. Fockler;D. Truran;J. Neuhaus;M. Weiner
背景重度抑郁障碍(MDD)的患病率随着年龄的增长而增加。与MDD相关的认知障碍的客观测量和主观报告通常都被认为随着年龄的增长而恶化。然而，很少有研究直接评估成年人一生中的这些特征。方法参与者包括23594名成年人，他们在在线研究登记中完成了客观和主观的认知测量。在21~40岁、41~60岁、61岁以上三个年龄组中，包括年龄组与抑郁的交互作用的线性回归被用来评估自我报告的MDD与认知测量的相关性。结果MDD(n=2127)在所有评估的领域中表现出比非抑郁者(ND；n=21467)更差的客观认知表现和更高的认知困难主观评分。与青年相比，中老年人的年龄组和MDD状况与主客观认知指标之间存在显著的交互作用，但中老年人之间的差异不显著。局限性本研究依赖于MDD诊断的自我报告，采用远程管理和无监督的认知测量，样本无差异。结论MDD与认知相关的程度在中年呈现平台期。我们的结果表明，痴呆率的增加并不是因为老年人中MDD的认知后果更大，年龄效应，而不是抑郁症的更大影响，可能会导致基于认知症状的主观报告而增加对MDD的诊断。
BackgroundMajor depressive disorder (MDD) has increasing prevalence with age. Both objective measures of cognitive dysfunction and subjective report of cognitive difficulties related to MDD are often thought to worsen with increasing age. However, few studies have directly evaluated these characteristics across the adult lifespan.MethodsParticipants included 23,594 adults completing objective and subjective measures of cognition on an online research registry. Linear regression including interactions of age group with depression was used to evaluate the association of self-reported MDD with measures of cognition in three age groups: 21–40 years; 41–60 years; 61+ years.ResultsMDD (n= 2127) demonstrated poorer objective cognitive performance and greater subjective ratings of cognitive difficulties across all domains assessed compared to non-depressed individuals (ND;n= 21,467). Significant interactions of age group and MDD status with objective and subjective measures of cognition were observed for both middle age and older adults when compared to young adults but few significant differences between middle-aged and older adults were evident.LimitationsThis study relied on self-report of MDD diagnosis, utilized remotely administered and unsupervised measures of cognition, and the sample was not diverse.ConclusionsThe magnitude of association between MDD and cognitive correlates appears to plateau in middle age. Our results suggest that increased rates of dementia are not due to greater cognitive consequence of MDD in older adults and that age effects, and not greater effects of depression, may lead to increased diagnosis of MDD based on subjective report of cognitive symptoms.