Chronic administration of phosphatidylserine during ontogeny enhances subject-environment interactions and radial maze performance in C57BL/6 mice
Chronic administration of phosphatidylserine during ontogeny enhances subject-environment interactions and radial maze performance in C57BL/6 mice
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在个体发育过程中长期施用磷脂酰丝氨酸可增强 C57BL/6 小鼠的受试者与环境相互作用和径向迷宫表现
DOI：
10.1016/0031-9384(90)90090-q
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发表时间：
1990
影响因子：
2.9
通讯作者：
F. Pavone
中科院分区：
文献类型：
--
作者：
M. Ammassari;S. Fagioli;M. Maritati;R. Populin;F. Pavone
对从出生到60天暴露于牛脑磷脂磷脂酰丝氨酸（BC-PS）的小鼠进行纵向行为研究。对给药和对照幼仔的检查显示，给药对体重和感觉运动反射均无影响。在一个月和两个月的年龄，当被放置在一个开放的领域，特别是在一个新的对象的存在下，治疗小鼠被发现比对照小鼠与他们的环境更互动。最后，当提交给一个径向八臂迷宫的问题，选择的准确性更高，迷宫运行策略更适应于治疗比对照成年小鼠。这些结果表明，在个体发育期间，治疗对受试者-环境相互作用的刺激作用是成年期认知能力改善的基础。
A longitudinal behavioral study was performed in mice exposed to the bovine brain phospholipid phosphatidylserine (BC-PS) from birth until sixty days. Examination of treated and control pups revealed no effect of the treatment on body weight nor on sensorimotor reflexes. At one and two months of age, when placed in an open field and, particularly, in the presence of a novel object, treated mice were found more interactive with their environment than control mice. Finally, when submitted to a radial eight-arm maze problem, choice accuracy was higher and maze-running strategies more adaptive in treated than in control adult mice. These results suggest a stimulating effect of the treatment on subject-environment interactions during ontogeny underlying improved cognitive abilities in adulthood.