Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM): A Molecular Assessment
Oxidative Stress, Biochemical and Histopathological Alterations in the Liver and Kidney of Female Rats Exposed to Low Doses of Deltamethrin (DM): A Molecular Assessment
复制标题
DOI：
10.3967/0895-3988.2012.06.009
复制
发表时间：
2012-12-01
影响因子：
3.5
通讯作者：
Bencheikh, Hassen
中科院分区：
文献类型：
--
作者：
Chargui, Issam;Grissa, Intissar;Bencheikh, Hassen
目的 探讨低剂量DM对雌性大鼠肝脏、肾脏的组织病理学改变及其潜在的基因毒性活性。方法将雌性Wistar大鼠随机分为对照组（3组，每组6只）和治疗组（3组，每组6只）。分别在30、45和60天后皮下注射DM（剂量为0.003、0.03和0.3 mg/kg bw/d）。 结果 肝空泡化、细胞核染色质碎片、血窦扩张和充血引起的肝实质发生显着改变。在肾脏中观察到近端肾小管和远端肾小管内的病变。肾小球内的组织充血和严重改变是可见的。 DM 作为拟除虫菊酯类杀虫剂引起显着增加 (P
Objective To evaluate histopathological alterations of the liver and kidney of female rats exposed to low doses of DM and its potential genotoxic activity.Methods Female Wistar rats were randomly assigned to control (3 groups, 6 rats in each) and treatment groups (3 groups, 6 rats in each). They were subjected to subcutaneous injections of DM (at doses of 0.003, 0.03, and 0.3 mg/kg bw/d) after 30, 45, and 60 d, respectively.Results Significant alterations were recorded in liver parenchyma induced by hepatic vacuolization, fragmented chromatin in nuclei, dilatation of sinusoids and congestions. Lesions within proximal and distal tubules were observed in the kidneys. Tissue congestions and severe alterations within glomeruli were visible. DM as a pyrethroid insecticide induced significant increase (P