A case-control study of ultraviolet radiation exposure, vitamin D, and lymphoma risk in adults
A case-control study of ultraviolet radiation exposure, vitamin D, and lymphoma risk in adults
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DOI：
10.1007/s10552-010-9554-1
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发表时间：
2010-08-01
影响因子：
2.3
通讯作者：
Fisher, Susan G.
中科院分区：
文献类型：
--
作者：
Kelly, Jennifer L.;Friedberg, Jonathan W.;Fisher, Susan G.
最近的研究表明，紫外线辐射暴露（UVRE），我们维生素D的主要来源，与淋巴瘤风险降低有关。动物和人类研究支持维生素D（vitD）不足与某些恶性肿瘤风险增加之间的关联。我们进行了一项基于临床的病例对照研究（140例淋巴瘤病例，139例对照; 2002-2005年，罗切斯特，NY），以评估UVRE和维生素D不足与淋巴瘤风险的关系。受试者完成调查并提供血液样本。我们使用多变量逻辑回归来估计淋巴瘤风险与过去（5-10年前）UVRE和当前维生素D不足（通过血清25（OH）D测定）的关系。探讨了淋巴瘤亚型效应的可能差异，但统计学把握度有限。我们证实了先前报道的淋巴瘤风险降低与过去的UVRE，特别是日光浴（>一次/周与从不）;调整的比值比（ORadj）= 0.28，95%置信区间（CI）：0.10-0.79。当前维生素D不足与淋巴瘤风险无关（ORadj = 0.89，95%CI：0.47-1.72）。然而，当前日光浴频率与血清25（OH）D值相关。因此，虽然我们的数据不支持与当前vitD状态的关联，但需要开发过去vitD评估的准确方法，以进一步研究其在过去UVRE和淋巴瘤风险之间的关联中的作用。
Recent research suggests that ultraviolet radiation exposure (UVRE), our major source of vitamin D, is associated with reduced lymphoma risk. Animal and human studies support an association between vitamin D (vitD) insufficiency and increased risk of some malignancies. We conducted a clinic-based case-control study (140 lymphoma cases, 139 controls; 2002-2005, Rochester, NY) to evaluate UVRE and vitD insufficiency in relation to lymphoma risk. Subjects completed a survey and provided a blood sample. We used multivariable logistic regression to estimate lymphoma risk in relation to past (5-10 years prior) UVRE and current vitD insufficiency (determined by serum 25(OH)D). Possible differences in effect by lymphoma subtype were explored, but statistical power was limited. We confirmed the previously reported decrease in lymphoma risk with past UVRE, specifically sunbathing (> once/week versus never); adjusted odds ratio (ORadj), = 0.28, 95% confidence interval (CI): 0.10-0.79. Current vitD insufficiency was not associated with lymphoma risk (ORadj = 0.89, 95% CI: 0.47-1.72). However, current sunbathing frequency was correlated with measured serum 25(OH)D values. Therefore, while our data do not support an association with current vitD status, development of accurate methods for past vitD assessment to further investigate its role in the association between past UVRE and lymphoma risk is warranted.