Magnetic properties of Zn-substituted MnFe2O4 nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells
Magnetic properties of Zn-substituted MnFe2O4 nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells
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DOI：
10.1021/cm1001708
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发表时间：
2010-10-12
影响因子：
8.6
通讯作者：
Ammar, S.
中科院分区：
文献类型：
--
作者：
Beji, Z.;Hanini, A.;Ammar, S.
采用多元醇法制备了化学计量比的Mn_（0.2）Zn_（0.8）Fe_2 O_4单分散纳米粒子。研究了零场冷却条件下磁化强度随磁场H（最高可达+/- 50 kOe）和温度（5-320 K）的变化。(ZFC)和现场冷却（FC）条件下对新生产的粉末进行处理。低场（H = 200 Oe）磁化率的T变化是具有低于室温的阻断温度的超顺磁体的特征。低温（T = 5 K）磁化强度的Id变化呈现磁滞回线。磁性很弱，约为0.2-0.3 kOe，这是典型的软亚铁磁性材料。0 K饱和磁化强度为98 emu.g（-1），居里温度为360 K。的磁性粒子的讨论与它们的化学组成和它们的阳离子分布的机会，使用它们作为加热介质在癌症治疗中的热疗应用。为此，还通过对人脐静脉内皮细胞（HUVEC）的活力测定来评价颗粒的毒性。
Stoichiometric Mn0.2Zn0.8Fe2O4 monodisperse nanoparticles were prepared by the so-called polyol method. The variation of magnetization as a function of magnetic field H (up to +/- 50 kOe) and temperature (5-320 K) were investigated, for zero-field-cooled. (ZFC) and field-cooled (FC) conditions on freshly produced powder. The T variation of the low-field (H = 200 Oe) magnetic susceptibility is characteristic of spperparamagnets with a blocking temperature below room temperature. The Id variation of the low temperature (T = 5 K) magnetization exhibits a hysteresis loop. The coercivity is weak, about 0.2-0.3 kOe, which is typical of soft-ferrimagnetic materials. The 0 K saturation magnetization and the Curie temperature are found to be 98 emu.g(-1) and 360 K, respectively. The magnetic properties of the particles are discussed in relation with their chemical composition and their cation distribution in the opportunity of using them as heating mediators for hyperthermia application in cancer therapy. In this aim, the toxicity of the particles was also evaluated by viability assays on human umbilical vein endothelial cells (HUVEC).