Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration
Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration
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DOI：
10.1016/j.neulet.2010.08.061
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发表时间：
2010-11
影响因子：
2.5
通讯作者：
K. Ueda;T. Nakahara;M. Hoshino;A. Mori;K. Sakamoto;K. Ishii
中科院分区：
文献类型：
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作者：
K. Ueda;T. Nakahara;M. Hoshino;A. Mori;K. Sakamoto;K. Ishii
视网膜缺血再灌注可引起毛细血管变性，但其损伤机制尚不清楚。NMDA受体在缺血再灌注后神经元损伤中起重要作用。因此，我们确定是否视网膜血管结构和功能受损的视网膜变性的大鼠模型由NMDA诱导。玻璃体内注射NMDA（200nmol）7d后，视网膜神经节细胞减少，内丛状层变薄。部分退化血管内皮细胞消失，空的基底膜袖残留。NMDA处理组视网膜基底膜袖状结构增多，损伤区可见无灌注血管。这些结果表明，在NMDA诱导的视网膜变性模型中，视网膜血管受损。神经元细胞可能在维持视网膜中血管系统的正常结构和功能中起作用。
Retinal ischemia–reperfusion causes capillary degeneration but the mechanisms of damage are not well understood. The NMDA receptor plays an important role in neuronal damage after ischemia–reperfusion. Therefore, we determined whether retinal blood vessels are damaged structurally and functionally in a rat model of retinal degeneration induced by NMDA. At 7 days after a single intravitreal injection of NMDA (200nmol) into the eye, loss of retinal ganglion cells and thinning of the inner plexiform layer were observed. Endothelial cells disappeared in some regressing vessels and empty basement membrane sleeves were left as remnants of the vessels. The number of basement membrane sleeves was increased in the NMDA-treated retina and non-perfused vessels were found in the injured retina. These results indicate that retinal blood vessels are damaged in the NMDA-induced retinal degeneration model. Neuronal cells may play a role in maintaining normal structure and function of the vasculature in the retina.