The effect of olfactory training on the odor threshold in patients with traumatic anosmia
The effect of olfactory training on the odor threshold in patients with traumatic anosmia
复制标题
DOI：
10.2500/ajra.2017.31.4466
复制
发表时间：
2017-09-01
影响因子：
2.6
通讯作者：
Liang, Kai-Li
中科院分区：
文献类型：
--
作者：
Jiang, Rong-San;Twu, Chih-Wen;Liang, Kai-Li
背景：嗅觉训练是一种新颖的干预措施，已用于治疗嗅觉功能障碍。本研究试图探讨嗅觉训练对创伤性嗅觉丧失患者的效果。方法：纳入有头部受伤后有明确嗅觉丧失病史且在类固醇和锌治疗后苯乙醇（PEA）气味检测阈值为 - 1 的患者。将患者随机分为两组，一组给予一瓶PEA，另一组给予一瓶矿物油，进行为期3个月的嗅觉训练。所有患者均接受PEA阈值测试和繁体中文版宾夕法尼亚大学气味识别测试（UPSIT-TC）进行随访。进行磁共振成像来测量嗅球的体积。任何 PEA 阈值结果低于 - 1.01 或 UPSIT-TC 评分增加 4 分或以上的患者均被认为嗅觉功能有所改善。 结果：42 名患者接受了 PEA 嗅觉训练，而 39 名患者接受了矿物油嗅觉训练。 PEA 组中有 10 名患者和矿物油组有 2 名患者观察到 PEA 阈值功能改善。 PEA 组阈值改善频率显着高于矿物油组。两组之间的嗅球体积和 UPSIT-TC 评分均无显着差异。结论：我们的结果表明，PEA 嗅觉训练可以提高创伤性嗅觉丧失患者的 PEA 气味阈值水平。
Background: Olfactory training is a novel intervention that has been used to treat olfactory dysfunction. This study attempted to investigate the effect of olfactory training in patients with traumatic anosmia.Methods: Patients with a clear history of anosmia after experiencing a head injury and whose phenyl ethyl alcohol (PEA) odor detection thresholds were - 1 after steroid and zinc treatment were included. The patients were randomly divided into two groups, with patients in one group given a bottle of PEA and those in another group given a bottle of mineral oil for 3-month olfactory training. All the patients were followed up with a PEA threshold test and the traditional Chinese version of the University of Pennsylvania Smell Identification Test (UPSIT-TC). Magnetic resonance imaging was performed to measure the volume of the olfactory bulbs. Any patient whose PEA threshold result was below - 1.01 or whose UPSIT-TC score increased four or more points was considered to have shown improvement in their olfactory function.Results: Forty-two patients received PEA olfactory training, whereas 39 received olfactory training with mineral oil. The improvement of PEA thresholds function was observed in 10 patients within the PEA group and in 2 patients in the mineral oil group. The frequency of improvement of threshold within the PEA group was significantly higher than that of the mineral oil group. Neither olfactory bulb volume nor UPSIT-TC score was significantly different between the two groups.Conclusion: Our results showed that olfactory training with PEA can improve PEA odor threshold levels in patients with traumatic anosmia.