Enteroendocrine hormones - central effects on behavior
Enteroendocrine hormones - central effects on behavior
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DOI：
10.1016/j.coph.2013.09.004
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发表时间：
2013-12-01
影响因子：
4
通讯作者：
Dickson, Suzanne L.
中科院分区：
文献类型：
--
作者：
Skibicka, Karolina P.;Dickson, Suzanne L.
许多调节食欲的胃肠激素改变了与奖励、焦虑/情绪、记忆和认知功能有关的行为，尽管对其中一些激素(特别是GLP-1和CCK)来说，内源性信号可能来自中枢神经系统。从生理学的角度来看，这些激素的分泌可能会因营养状况和减肥手术而改变，它们协调的神经生物学效应是综合的，并与喂养/代谢控制有关。与饥饿和进食启动过程中的作用一致，Ghrelin增加了对食物的动机行为，并且在食物不容易获得的情况下，减少了焦虑测试中的行为，否则这些行为会阻碍动物寻找食物。在许多厌食信号中，GLP-1和PYY被认为与一种受抑制的奖赏功能有关，而CCK(可能还有GLP-1)与焦虑样行为的增加有关。
A number of appetite-regulating gut hormones alter behaviors linked to reward, anxiety/mood, memory and cognitive function, although for some of these (notably GLP-1 and CCK) the endogenous signal may be CNS-derived. From a physiological perspective it seems likely that these hormones, whose secretion is altered by nutritional status and by bariatric weight loss surgery, orchestrate neurobiological effects that are integrated and linked to feeding/metabolic control. Consistent with a role in hunger and meal initiation, ghrelin increases motivated behavior for food and, when food is not readily available, decreases behaviors in anxiety tests that would otherwise hinder the animal from finding food. Of the many anorexigenic signals, GLP-1 and PYY have been linked to a suppressed reward function and CCK (and possibly GLP-1) to increased anxiety-like behavior.