Akt1, EMSY, BRCA2 and type I IFN signaling A novel arm of the IFN response
Akt1, EMSY, BRCA2 and type I IFN signaling A novel arm of the IFN response
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DOI：
10.4161/trns.21904
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发表时间：
2012-01-01
影响因子：
3.6
通讯作者：
Tsichlis, Philip N.
中科院分区：
文献类型：
--
作者：
Ezell, Scott A.;Tsichlis, Philip N.
干扰素刺激的转录被认为主要通过JAK/STAT途径的作用发生。然而，最近的发现揭示了另一个依赖PI3K/Akt的途径，该途径有助于通过调节转录抑制因子EMSY来诱导一系列干扰素刺激基因(ISGs)的产生。
Interferon-stimulated transcription is thought to occur mainly through the action of the JAK/STAT pathway. However, recent findings revealed an additional PI3K/Akt-dependent pathway, which contributes to the induction of a set of interferon-stimulated genes (ISGs) through the regulation of the transcriptional repressor EMSY.