HYDRATION HYDRATE ACIDITY AND ALDOLIZATION OF ISOBUTYRALDEHYDE
HYDRATION HYDRATE ACIDITY AND ALDOLIZATION OF ISOBUTYRALDEHYDE
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DOI：
10.1021/jo01015a054
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发表时间：
1965-01-01
影响因子：
3.6
通讯作者：
JENSEN, JH
中科院分区：
文献类型：
--
作者：
HINE, J;HOUSTON, JG;JENSEN, JH
用核磁共振和紫外光谱测定了异丁醛在水溶液中水合和羟醛缩合反应的平衡常数。本文还研究了水合异丁醛的酸性和异丁醛醛的脱羟反应动力学。从动力学研究看来，异丁醛碳负离子与异丁醛分子的结合在速率上与其质子化相当，因此在dealdolization中的速率控制步骤可能随着所用碱性催化剂的性质的变化而变化。
The equilibrium constants for thehydration and the aldolization of isobutyraldehyde in aqueous solution have been determinedby nmr and ultraviolet measurements. The acidity of isobutyraldehyde hydrate and the kinetics of the dealdolization of isobutyraldol have also been studied. From the kinetic study it appears that the combination of an isobutyraldehyde carbanion with an isobutyraldehyde molecule is comparable in rate to its protonation, so that the rate-controlling step in dealdolization may change with a change in the nature of the basic catalyst used.