The role of altered lipoproteins in the pathogenesis of atherosclerosis.
The role of altered lipoproteins in the pathogenesis of atherosclerosis.
复制标题
脂蛋白改变在动脉粥样硬化发病机制中的作用。
DOI：
10.1016/0002-8703(87)90635-1
复制
发表时间：
1987
影响因子：
4.8
通讯作者：
Fogelman,AM
中科院分区：
文献类型：
--
作者：
Haberland,ME;Fogelman,AM
改变的脂蛋白，特别是低密度脂蛋白（LDL），有助于动脉粥样硬化反应的启动或传播，这一概念的出现是我们对富含胆固醇酯的脂蛋白代谢的理解最近取得进展的结果。体外研究表明，脂蛋白改变是在动脉粥样硬化病变的泡沫细胞内产生大量胆固醇酯沉积的先决条件。“产生这种效果的改变脂蛋白包括通过化学或细胞修饰或与其他分子复合物改变的低密度脂蛋白，以及# i -迁移极低密度脂蛋白@ VLDL)。”“这些研究引起的科学兴趣在与动脉粥样硬化病变发展相关的时间和生化事件的背景下得到了最好的理解。”现在有大量证据表明，血液单核细胞在动脉粥样硬化的发病过程中起着早期作用，并且是动脉病变中许多泡沫细胞的祖细胞。最近的形态学研究（4-6,g* lo）系统地记录了慢性饮食诱导的高胆固醇血症在动脉粥样硬化发展过程中病变中发生的连续细胞事件
The concept that altered lipoproteins, particularly low-density lipoproteins (LDL), contribute to the initiation or propagation of the atherosclerotic reaction has emerged as a consequence of recent advances in our understanding of the metabolism of cholesteryl ester-rich lipoproteins. In vitro studies have implicated lipoprotein alteration as a prerequisite to producing the massive deposition of cholesteryl esters within the foam cells of the atherosclerotic lesion.’Altered lipoproteins producing this effect include LDL altered by chemical or cellular modification or complexed with other molecules, as well as# I-migrating very low-density lipoproteins@ VLDL).’The scientific interest aroused by these investigations is best understood in the context of the temporal and biochemical events associated with the development of the atherosclerotic lesion. There is now substantial evidence that blood monocytes play an early role in the pathogenesis of atherosclerosis and are progenitors of many of the foam cells of the arterial lesion. 2-11 Recent morphologic studies4-6, g* lo have systematically documented the sequential cellular events occurring in lesions during the development of atherosclerosis induced by chronic, diet-induced hypercholesterolemia in