CHANGES IN VOLTAGE DEPENDENCE OF NMDA CURRENTS DURING DEVELOPMENT
CHANGES IN VOLTAGE DEPENDENCE OF NMDA CURRENTS DURING DEVELOPMENT
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DOI：
10.1016/0304-3940(88)90275-3
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发表时间：
1988-11-22
影响因子：
2.5
通讯作者：
KRNJEVIC, K
中科院分区：
文献类型：
--
作者：
BENARI, Y;CHERUBINI, E;KRNJEVIC, K
N-Methyl-D-aspartase (NMDA), applied by superfusion to hippocampal slices evokes comparable peak inward currents in CA3 pyramidal cells of adult and 0-10 day-old rats. However, NMDA current-voltage plots from immature neurons do not consistently show the region of negative slope conductance characteristic of adult. Therefore at a critical stage of development, NMDA activation may elicit substantial inward currents and Ca2+ influx at resting membrane potential.
