Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
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DOI：
10.1021/ol061975c
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发表时间：
2006-11-09
期刊：
影响因子：
5.2
通讯作者：
Tranmer, Geoffrey K.
中科院分区：
文献类型：
--
作者：
Baumann, Marcus;Baxendale, Ian R.;Tranmer, Geoffrey K.
一个多用途的mesofluidic流动反应器能够产生克数量的材料已经开发作为一个自动化的合成平台，快速按需合成的关键构件和小的探索性图书馆。该反应器被配置为提供最大的灵活性，用于筛选反应参数，该反应参数包括芯片上混合和固体支撑试剂柱，以加快化学合成。
A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide the maximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expedite the chemical syntheses.