Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice.
Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice.
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DOI：
10.18632/aging.202627
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发表时间：
2021-02-26
期刊：
影响因子：
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通讯作者：
Sun C
中科院分区：
文献类型：
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作者：
Huang J;Shan W;Li F;Wang Z;Cheng J;Lu F;Guo E;Beejadhursing R;Xiao R;Liu C;Yang B;Li X;Fu Y;Xi L;Wang S;Ma D;Chen G;Sun C
外阴阴道萎缩（VVA）是一种常见的更年期相关症状，影响超过50%的中老年女性和卵巢功能丧失或受损的癌症患者。无论雌激素缺乏与否，肠道微生物群等其他因素是否在VVA中发挥作用尚未得到彻底研究。为此，我们对12周龄的小鼠进行了卵巢切除术，并在卵巢切除术后4周进行了随访，观察到卵巢切除小鼠的阴道萎缩和肠道微生物群改变。我们进一步将来自另一组卵巢完整的多育雌性小鼠的粪便移植到卵巢切除的小鼠中，发现阴道上皮萎缩显著减轻，肠道微生物群也发生了明显变化。这些结果表明卵巢活动对肠道菌群有一定影响，卵巢完整小鼠的肠道菌群可能通过上调阴道细胞中ESR1的表达，促进阴道再生，从而使卵巢功能缺陷小鼠的阴道更加健康。肠道微生物群与阴道健康之间的这种关联需要进一步探索，以便它可以通过调节患有VVA但可能不愿意激素治疗的患者的肠道微生物群来提供替代治疗。
Vulvovaginal atrophy (VVA) is a common menopause-related symptom affecting more than 50% of midlife and older women and cancer patients whose ovarian function are lost or damaged. Regardless of estrogen deficiency, whether other factors such as the gut microbiota play role in VVA have not been thoroughly investigated. To this end, we performed ovariectomy on 12-weeks’ old mice and follow-up at 4 weeks after ovariectomy, and observed atrophied vagina and an altered gut microbiota in ovariectomized mice.. We further performed fecal microbiota transplantation with feces from another cohort of ovary-intact fecund female mice to the ovariectomized ones, and found that the vaginal epithelial atrophy was significantly alleviated as well as the gut microbiota was pointedly changed. All these results suggest that ovarian activity has some influence on the gut microbiota, and the latter from the ovary-intact female mice can somehow make the vagina of mice deficient in ovarian function healthier maybe by up-expressing ESR1 in vaginal cells and enhancing regeneration in vagina. This kind of association between gut microbiota and vaginal health need further exploration such that it may provide an alternative treatment by modulating gut microbiota in patients suffering from VVA but may be reluctant to hormone therapy.