Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246
Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246
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DOI：
10.1016/j.bmcl.2008.10.032
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发表时间：
2008-12-01
影响因子：
2.7
通讯作者：
Kimura, Ken-ichi
中科院分区：
文献类型：
--
作者：
Shiono, Yoshihito;Shimanuki, Keiko;Kimura, Ken-ichi
从水稻内生真菌Neonectria ramulariae Wollenw KS-246的糙米培养物中分离到吡咯螺酮A和吡咯螺酮B。它们的绝对立体结构(1和2)通过一维和二维核磁共振技术的光谱方法和化学转化，包括改进的Mosher方法被阐明。这些化合物对人早幼粒白血病HL-60细胞具有细胞毒作用和诱导凋亡作用。(C)2008爱思唯尔有限公司。保留所有权利。
Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells. (C) 2008 Elsevier Ltd. All rights reserved.