Differential regulation of anaphase promoting complex/cyclosome substrates by the spindle assembly checkpoint in Saccharomyces cerevisiae
Differential regulation of anaphase promoting complex/cyclosome substrates by the spindle assembly checkpoint in Saccharomyces cerevisiae
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DOI：
10.1534/genetics.107.083642
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发表时间：
2008-01-01
期刊：
影响因子：
3.3
通讯作者：
Burke, Daniel J.
中科院分区：
文献类型：
--
作者：
Keyes, Brice E.;Yelhnan, Christopher M.;Burke, Daniel J.
后期促进复合物（APC）靶向蛋白质降解，以促进细胞周期的进展。在这里，我们表明，Clb 5，APC（Cdc20）基板，降解时，纺锤体检查点是活跃的，而其他APC（Cdc20）基板是稳定的，这表明，APC（Cdc20）抑制纺锤体检查点是基板特异性。
The anaphase promoting complex (APC) targets proteins for degradation to promote progression through the cell cycle. Here we show that Clb5, an APC(Cdc20) substrate, is degraded when the spindle checkpoint is active, while other APC(Cdc20) substrates are stabilized, Suggesting that APC(Cdc20) inhibition by the spindle checkpoint is substrate specific.