Single-Scan 13C Diffusion- Ordered NMR Spectroscopy of DNP-Hyperpolarised Substrates
Single-Scan 13C Diffusion- Ordered NMR Spectroscopy of DNP-Hyperpolarised Substrates
复制标题
DOI：
10.1002/chem.201703300
复制
发表时间：
2017-11-27
影响因子：
4.3
通讯作者：
Dumez, Jean-Nicolas
中科院分区：
文献类型：
--
作者：
Guduff, Ludmilla;Kurzbach, Dennis;Dumez, Jean-Nicolas
扩散有序核磁共振谱（DOSY）是一种分析分子混合物的有效方法，但其应用范围受到核磁共振灵敏度相对较低的限制。我们在这里表明，光谱分辨C-13 DOSY数据可以收集，在一个单一的扫描，超极化的溶解动态核极化（D-DNP），它提供了几个数量级的信号增强基板。为此，我们使用对流补偿脉冲方案，我们也分析了数值模拟。所提出的方法还允许在单个D-DNP实验中采集几个连续的DOSY光谱。
Diffusion-ordered NMR spectroscopy (DOSY) is a powerful approach for the analysis of molecular mixtures, yet its application range is limited by the relatively low sensitivity of NMR. We show here that spectrally resolved C-13 DOSY data can be collected, in a single scan, for substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP), which provides signal enhancements of several orders of magnitude. For this we use a convection-compensation pulse scheme, which we also analyse by numerical simulation. The proposed method further allows the acquisition of several consecutive DOSY spectra in a single D-DNP experiment.