Levo propoxyphene and respiratory tract fluid.
Levo propoxyphene and respiratory tract fluid.
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左旋丙氧芬和呼吸道液体。
DOI：
10.1177/009127006200200102
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发表时间：
1962
期刊：
影响因子：
--
通讯作者：
E. M. Boyd
中科院分区：
文献类型：
--
作者：
C. E. Boyd;E. M. Boyd
方法实验在健康、年轻的CBL兔和猫身上进行。对于通过胃插管给药的动物，在给药前16小时禁食。用腹膜内给予平均1Gm剂量的乌拉坦将动物轻度麻醉。每公斤。体重。然后安排他们按照本实验室使用的方法收集呼吸道液体。'-“在给药前三小时的对照期内，每小时测量呼吸道液体的正常排出量。通过皮下注射和胃插管给予左旋丙氧芬。对于皮下注射，将药物以溶解在每公斤体重1.00毫升无菌蒸馏水中的盐酸盐形式注射，除了在最高剂量为每公斤体重 9、27、81、243 和 729 毫克。口服剂量为每公斤体重10毫升。
MethodsThe experiments were performed upon healthy, young CBL rabbits and cats. For animals dosed by gastric intubation, food was withdrawn for 16 hours before administration of the drug. The animals were lightly anesthetized with urethane given intraperitoneally in a dose which averaged 1 Gm. per kg. body weight. Thev were then arranged for the collection· of respiratory tract fluid after methods in use in this laboratorv.'-" The normal output of respiratory tract fluid was measured hourly for a control period of three hours before administration of the drug. Levo propoxyphene was given by subcutaneous injection and bv gastric intubation. For s~ bcutaneous i~ jection, the drug was injected as the hydrochloride dissolved in 1.00 ml. sterilized distilled water per kg. body weight, except in the instance of the highest dose which required 3.00 ml. per kg. Doses given by subcutaneous injection were 9, 27, 81, 243, and 729 mg. per kg. body weight. For oral administration, levo propoxyphene was given as the 2-naphthalene sulfonate, which was suspended in a 0.25 per cent solution of gum tragacanth in distilled water and administered by gastric intubation in a volume of 10 ml. per kg. body weight. Doses given orally were 2, 10, 50, 250, and 1250 mg. per kg. body weight.