Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus function.
Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus function.
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DOI：
10.3758/cabn.10.2.252
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Cohen JD
中科院分区：
文献类型：
--
作者：
Gilzenrat MS;Nieuwenhuis S;Jepma M;Cohen JD
认知控制的一个重要方面是适应性调节利用（追求已知的奖励来源）和探索（寻找新的）之间的平衡，以应对任务效用的变化。最近的研究表明，蓝斑-去甲肾上腺素系统可能在这一功能中发挥重要作用，瞳孔直径可用于指示蓝斑活动。在此基础上，我们推断瞳孔直径可能与控制状态和相关的行为变化密切相关。具体来说，我们预测，基线瞳孔直径的增加将与任务效用的降低和脱离任务（探索）相关，而基线直径的降低（但任务诱发的扩张增加）将与任务参与（开发）相关。在三个实验中的结果与这些预测是一致的，这表明瞳孔测量可能是有用的控制状态和，间接，蓝斑功能的指标。
An important dimension of cognitive control is the adaptive regulation of the balance between exploitation (pursuing known sources of reward) and exploration (seeking new ones) in response to changes in task utility. Recent studies have suggested that the locus coeruleus–norepinephrine system may play an important role in this function and that pupil diameter can be used to index locus coeruleus activity. On the basis of this, we reasoned that pupil diameter may correlate closely with control state and associated changes in behavior. Specifically, we predicted that increases in baseline pupil diameter would be associated with decreases in task utility and disengagement from the task (exploration), whereas reduced baseline diameter (but increases in task-evoked dilations) would be associated with task engagement (exploitation). Findings in three experiments were consistent with these predictions, suggesting that pupillometry may be useful as an index of both control state and, indirectly, locus coeruleus function.