Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin
Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin
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DOI：
10.2302/kjm.2011-0002-ir
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发表时间：
2012-12-01
影响因子：
2
通讯作者：
Kubota, Yoshiaki
中科院分区：
文献类型：
--
作者：
Kishi, Kazuo;Okabe, Keisuke;Kubota, Yoshiaki
哺乳动物胎儿的皮肤创伤在一定的发育阶段之前，会迅速愈合，没有疤痕，皮肤完全再生。在胎儿伤口愈合过程中，未观察到成人中观察到的炎症反应、肉芽增生和瘢痕形成。从分子生物学和细胞生物学的角度，许多研究报道了胎儿无瘢痕皮肤再生的原因，包括TGF-β 1表达减少和细胞外基质中透明质酸水平升高，但其机制尚未完全了解。尽管已经研究了多种抑制瘢痕形成的物质，但目前成人皮肤伤口几乎不可能完全愈合而无瘢痕。除了少数动物物种，创伤后的完全再生只能发生在妊娠期。通过严格比较皮肤再生到瘢痕形成前后的阶段，将有可能研究皮肤再生的机制。(doi 2011 -0002-IR; Keio J Med 61（4）：101-108，2012年12月）
Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, inflammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-beta 1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration. (doi: 10.2302/kjm.2011-0002-IR; Keio J Med 61 (4) : 101-108, December 2012)