Experimental cranioplasty and skeletal augmentation using an alpha-tricalcium phosphate/dicalcium phosphate dibasic/tetracalcium phosphate monoxide cement: a preliminary short-term experiment in rabbits.
Experimental cranioplasty and skeletal augmentation using an alpha-tricalcium phosphate/dicalcium phosphate dibasic/tetracalcium phosphate monoxide cement: a preliminary short-term experiment in rabbits.
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使用α-磷酸三钙/磷酸氢二钙/一氧化磷酸四钙骨水泥进行实验性颅骨成形术和骨骼增强：在兔子中进行的初步短期实验。
DOI：
10.1016/s0142-9612(97)00178-6
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发表时间：
1998
期刊：
影响因子：
14
通讯作者：
M. Hirano
中科院分区：
文献类型：
--
作者：
K. Kurashina;H. Kurita;A. Kotani;S. Kobayashi;K. Kyoshima;M. Hirano
将由α-磷酸三钙（α-TCP）、磷酸二钙（DCPD）和磷酸四钙（TeCP）组成的磷酸钙骨水泥植入手术造成的颅骨全层缺损（骨缺损实验），并直接植入骨膜下的颅骨（增强实验）。植入3个月后，将植入物与周围组织一起取出，进行组织学和显微摄影研究，以评估骨水泥是否可以用作颅骨成形术和骨骼增强材料。在骨缺损实验中，12例标本中有8例缺损成功重建。在植入时出血控制困难的4个标本显示水泥部分丢失。成功植入骨水泥的组织学和显微放射学研究显示，新骨几乎完全包围了种植体，并直接与骨水泥表面结合。在增强实验中，增强区保持半球形，并与宿主骨紧密连接。组织学和显微x线摄影显示，在骨水泥与宿主骨之间的间隙以及种植体边缘骨水泥的外表面（骨膜侧）可见新骨形成。从这个初步的短期研究中，可以得出结论，该水泥具有良好的骨导电性，是一种有前景的颅骨成形术和骨骼增强材料。
Calcium phosphate cement consisting of α-tricalcium phosphate (α-TCP), dicalcium phosphate dibasic (DCPD) and tetracalcium phosphate monoxide (TeCP) was implanted into surgically created full-thickness defects in the cranial bone (bone defect experiment) and directly onto the cranial bone under the periosteum (augmentation experiment). Three months after the implantation, the implants were retrieved with the surrounding tissues and studied histologically and micrographically to evaluate if the cement can be used as a cranioplasty and skeletal augmentation material. In the bone defect experiment, successful reconstruction of the defect was seen in 8 out of 12 specimens. Four specimens, where bleeding control was difficult at the time of implantation, showed partial loss of the cement. Histological and microradiographic studies of the successfully implanted cement revealed that new bone surrounded the implant nearly completely and united directly with the cement surface. In the augmentation experiment, the augmented area maintained the hemispherical shape and was connected tightly with the host bone. Histology and microradiography demonstrated that new bone formation was seen in the gap between the cement and the host bone, and on the outer surface (periosteum side) of the cement at the edge of the implant. From this preliminary short-term study, it could be concluded that the cement is a promising material for cranioplasty and skeletal augmentation with indications that it has good osteoconductivity.