What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease.
What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2016.11.007
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发表时间：
2017-03
影响因子：
4.2
通讯作者：
Federoff HJ
中科院分区：
文献类型：
--
作者：
Mapstone M;Lin F;Nalls MA;Cheema AK;Singleton AB;Fiandaca MS;Federoff HJ
As the world population ages, primary prevention of age-related cognitive decline and disability will become increasingly important. Prevention strategies are often developed from an understanding of disease pathobiology, but models of biological success may provide additional useful insights. Here, we studied 224 older adults, some with superior memory performance (n=41), some with normal memory performance (n=109), and some with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) (n=74) to understand metabolomic differences which might inform future interventions to promote cognitive health. Plasma metabolomics revealed significant differential abundance of 12 metabolites in those with superior memory relative to controls (ROC AUC = 0.89) and the inverse abundance pattern in the MCI, AD (AUC = 1.0) and even preclinical AD groups relative to controls (AUC = 0.97). The 12 metabolites are components of key metabolic pathways regulating oxidative stress, inflammation, and nitric oxide bioavailability. These findings from opposite ends of the cognitive continuum highlight the role of these pathways in superior memory abilities and whose failure may contribute to age-related memory impairment. These pathways may be targeted to promote successful cognitive aging.
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影响因子：
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影响因子：
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