Effect of tamoxifen alone and in combination with RU 486 on the endometrium in the mid-luteal phase.
Effect of tamoxifen alone and in combination with RU 486 on the endometrium in the mid-luteal phase.
复制标题
单独使用他莫昔芬以及与 RU 486 联用对黄体中期子宫内膜的影响。
DOI：
10.1093/oxfordjournals.humrep.a138021
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发表时间：
1993
影响因子：
6.1
通讯作者：
S. Cekan
中科院分区：
文献类型：
--
作者：
M. Swahn;M. Bygdeman;M. Seppala;E. Johannisson;S. Cekan
研究了RU 486与他莫昔芬联合使用和他莫昔芬单独使用对着床时激素参数和子宫内膜发育的影响。子宫内膜中胞浆雌激素和孕激素受体以及血浆中胎盘蛋白14（PP14）的测定也包括在内。使用了三种剂量方案：单次口服剂量40 mg他莫昔芬单独和与200 mg RU 486组合，以及40 mg他莫昔芬连续三天，从促黄体生成素（LH）激增后的第一天开始。联合用药可延长黄体期（P < 0.05），提高血浆孕酮水平。单剂量他莫昔芬不影响出血模式和血浆激素水平，但3天治疗后血浆雌二醇和LH升高。联合用药和三苯氧胺治疗3天后，子宫内膜发育迟缓。联合治疗后，胞浆孕酮受体浓度升高，但仅他莫昔芬治疗后不受影响。重复他莫昔芬剂量后PP14水平高于对照组（P < 0.05），但联合治疗后低于对照组。在月经周期的分泌期，孕激素和雌激素显然是子宫内膜成熟所必需的。血浆中PP14水平不能用于子宫内膜功能的临床评估，因为高水平与子宫内膜发育紊乱一致。
The effects of RU 486 combined with tamoxifen and tamoxifen alone on hormonal parameters and endometrial development at the time of implantation were studied. Measurements of cytosolic oestrogen and progesterone receptors in endometrium and placental protein 14 (PP14) in plasma were also included. Three dosage schedules were used: single oral dose of 40 mg tamoxifen alone and in combination with 200 mg RU 486, and 40 mg tamoxifen for three consecutive days starting on the first day after the luteinizing hormone (LH) surge. The combined treatment prolonged the luteal phase (P < 0.05) and increased the plasma levels of progesterone. A single dose of tamoxifen did not affect the bleeding pattern and plasma hormone levels, but raised plasma oestradiol and LH with the 3-day treatment. The endometrium was retarded after the combined and the 3-day treatment with tamoxifen. Concentrations of cytosolic progesterone receptors were higher after the combined therapy, but were unaffected after tamoxifen only. PP14 levels were higher (P < 0.05) after repeated tamoxifen doses than in controls, but were lower with combined treatment. Progesterone and oestrogen are evidently necessary for endometrial maturation during the secretory phase of the menstrual cycle. PP14 levels in plasma cannot be used for clinical assessments of endometrial function because high levels coincide with disturbed endometrial development.