Diffusion tensor imaging and behavior in premature infants at 8 years of age, a randomized controlled trial with long-chain polyunsaturated fatty acids
Diffusion tensor imaging and behavior in premature infants at 8 years of age, a randomized controlled trial with long-chain polyunsaturated fatty acids
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DOI：
10.1016/j.earlhumdev.2016.01.021
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发表时间：
2016-04-01
影响因子：
2.5
通讯作者：
Drevon, Christian A.
中科院分区：
文献类型：
--
作者：
Almaas, Astrid Nylander;Tamnes, Christian K.;Drevon, Christian A.
背景：极低出生体重(VLBW，出生体重和1500克)的儿童患行为问题的风险增加。脑部扩散张量成像(DTI)显示脑白质成熟减少。长链多不饱和脂肪酸被认为可以改善髓鞘形成和行为结果。目的：检验出生后补充二十二碳六烯酸(DHA)和花生四烯酸(AA)会影响DTI测量的脑白质并改善8岁时行为结局的假说。研究设计：一项随机、双盲、安慰剂对照研究，对129名喂养母乳的VLBW婴儿出生后补充DHA和AA进行8年的随访。采用强项与困难问卷和儿童行为量表精选量表测量行为结果。结果：干预组和对照组在脑白质显微结构和行为数据上无明显差异。结论：本研究是首次用DHA和AA对母乳喂养的VLBW婴儿进行随机对照试验，通过DTI测量脑白质微结构和父母报告的行为问题进行长期随访。在8岁时，没有观察到对脑白质微结构或行为结果的影响。(C)2016爱思唯尔爱尔兰有限公司。保留所有权利。
Background: Very low birth weight (VLBW, birth weight < 1500 g) children have increased risk of behavioral problems. Diffusion tensor imaging (DTI) of the brain shows reduced white matter maturation. Long-chain polyunsaturated fatty acids are hypothesized to improve both myelination and behavioral outcome.Aims: TO test the hypothesis that postnatal supplementation with docosahexaenoic acid (DHA) and arachidonic acid (AA) to very low birth weight infants would influence cerebral white matter measured by DTI and improve behavioral outcome at 8 years of age.Study design: Eight-year follow-up of a randomized, double-blinded, placebo-controlled study of postnatal supplementation with DHA and AA to 129 VLBW infants fed human milk.Subjects: Ninety-eight children (76%) met for follow-up at 8 years.Outcome measures: Cerebral white matter measured by DTI. Behavioral outcome measured by Strengths and Difficulties questionnaire and selected scales from the Child Behavior ChecklistResults: No significant differences between the intervention group and the control group were found on white matter microstructure or behavioral data. A non-significant finding of higher fractional anisotropy (FA) in a cluster in the corpus callosum of the intervention group is discussed.Conclusions: The present study is the first long-term follow-up of a randomized controlled trial with DHA and AA to human milk fed VLBW infants exploring cerebral white matter microstructure measured by DTI and parent-reported behavioral problems. No effects on white matter microstructure or behavioral outcome were observed at 8 years of age. (C) 2016 Elsevier Ireland Ltd. All rights reserved.