Peripheral neuropathy in type 2 diabetes mellitus in Isfahan, Iran: prevalence and risk factors
Peripheral neuropathy in type 2 diabetes mellitus in Isfahan, Iran: prevalence and risk factors
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DOI：
10.1111/j.1600-0404.2006.00716.x
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发表时间：
2006-12-01
影响因子：
3.5
通讯作者：
Amini, M.
中科院分区：
文献类型：
--
作者：
Janghorbani, M.;Rezvanian, H.;Amini, M.
背景 - 评估 2 型糖尿病患者周围神经病变 (PN) 的患病率和危险因素。方法 - 对来自伊朗伊斯法罕内分泌和代谢研究中心门诊部的 810 名 2 型糖尿病患者（289 名男性和 521 名女性）进行了检查。检查的一部分包括评估神经功能，包括神经病症状和体征以及神经传导速度。结果 - PN 患病率为 75.1%（95% 置信区间 72.1、78.0）。 PN 与年龄、蛋白尿、糖尿病病程、胰岛素治疗以及任何视网膜病变和缺血性心脏病 (IHD) 的存在相关。经年龄调整的 PN 患病率在 IHD 患者中高出 78%，在患有任何视网膜病变的患者中高出 64%，在接受胰岛素治疗的 2 型糖尿病患者中高出 66%，并且随着糖尿病病程的延长而升高。使用逐步二元 Logistic 回归模型，年龄、糖尿病病程和蛋白尿是 PN 的显着独立预测因子。结论 - 周围神经病变是伊朗 2 型糖尿病患者的常见并发症。它随着年龄、糖尿病病程和蛋白尿的持续时间而增加。
Background - To estimate the prevalence and risk factors of peripheral neuropathy (PN) in people with type 2 diabetes mellitus. Methods - A total of 810 patients with type 2 diabetes (289 men and 521 women) from Isfahan Endocrinology and Metabolism Research Centre outpatient clinics, Iran, were examined. Part of examination included an assessment of neurological function including neuropathic symptoms and physical signs and nerve conduction velocity. Results - The prevalence of PN was 75.1% (95% confidence interval 72.1, 78.0). PN was associated with age, proteinuria, and duration of diabetes, insulin-treatment, and presence of any retinopathy and ischaemic heart disease (IHD). The age-adjusted prevalence rate of PN was 78% higher among patients with IHD, 64% higher among patients with any retinopathy, 66% higher among insulin-treated type 2 diabetes, and it was greater with duration of diabetes. Using a stepwise binary logistic regression model, age, duration of diabetes and proteinuria were significant independent predictors of PN. Conclusion - Peripheral neuropathy is a common complication in this population of Iranian type 2 diabetic patients. It increases with age, duration of diabetes and proteinuria.