SEROLOGIC PRECURSORS OF CANCER - RETINOL, CAROTENOIDS, AND TOCOPHEROL AND RISK OF PROSTATE-CANCER
SEROLOGIC PRECURSORS OF CANCER - RETINOL, CAROTENOIDS, AND TOCOPHEROL AND RISK OF PROSTATE-CANCER
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DOI：
10.1093/jnci/82.11.941
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发表时间：
1990-06-06
影响因子：
10.3
通讯作者：
POLK, BF
中科院分区：
文献类型：
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作者：
HSING, AW;COMSTOCK, GW;POLK, BF
我们研究了血清视黄醇、类胡萝卜素β-胡萝卜素、番茄红素和生育酚（维生素E）与前列腺癌风险之间的关系。本研究使用了1974年从华盛顿县[马里兰州，美国]的25，802人中获得的血清。在随后的13年中，103名前列腺癌患者的血清营养素水平与103名年龄和种族匹配的对照组进行了比较。虽然没有观察到与β-胡萝卜素、番茄红素或生育酚，数据表明血清视黄醇与前列腺癌风险呈负相关。我们用四分位数分析了血清视黄醇的分布数据，使用最低的四分位数作为参考值。第二、第三和最高四分位数的优势比分别为0.67、0.39和0.40。
We investigated the associations of serum retinol, the carotenoids .beta.-carotene and lycopene, and tocopherol (vitamin E) with the risk of prostate cancer in a nested case-control study. For the study, serum obtained in 1974 from 25,802 persons in Washington County, [Maryland, USA], was used. Serum levels of the nutrients in 103 men who developed prostate cancer during the subsequent 13 years were compared with levels in 103 control subjects matched for age and race. Although no significant associations were observed with .beta.-carotene, lycopene, or tocopherol, the data suggested an inverse relationship between serum retinol and risk of prostate cancer. We analyzed data in the distribution of serum retinol by quartiles, using the lowest quartile as the reference value. Odds ratios were 0.67, 0.39, and 0.40 for the second; third, and highest quartiles, respectively.