Model-based evolutionary analysis: the natural history of phage-shock stress response
Model-based evolutionary analysis: the natural history of phage-shock stress response
复制标题
DOI：
10.1042/bst0370762
复制
发表时间：
2009-08-01
影响因子：
3.9
通讯作者：
Stumpf, Michael P. H.
中科院分区：
文献类型：
--
作者：
Huvet, Maxime;Toni, Tina;Stumpf, Michael P. H.
蛋白质的进化与其功能密不可分。由于大多数生物过程涉及许多不同的蛋白质，因此孤立地研究蛋白质的进化特性可能变得不可能。在这篇文章中，我们展示了生物过程的简单机械模型如何补充传统的生物性状比较分析。我们使用噬菌体休克应激反应的具体例子，这已在大肠杆菌中得到很好的表征，阐明跨细菌物种的基因共享和序列保守的模式。
The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can complement conventional comparative analyses of biological traits. We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species.