Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer.
Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer.
复制标题
DOI：
10.1002/mrm.24520
复制
发表时间：
2012-12
影响因子：
3.3
通讯作者：
van Zijl, Peter C. M.
中科院分区：
文献类型：
--
作者：
Chan, Kannie W. Y.;McMahon, Michael T.;Kato, Yoshinori;Liu, Guanshu;Bulte, Jeff W. M.;Bhujwalla, Zaver M.;Artemov, Dmitri;van Zijl, Peter C. M.
现代成像技术如CT、PET、SPECT和MRI使用造影剂来可视化肿瘤微环境，提供关于恶性肿瘤和对治疗的反应的信息。目前，所有临床成像剂都需要化学标记，即用碘（CT）、放射性同位素（PET/SPECT）或顺磁金属（MRI）标记。目的是探索使用简单的D-葡萄糖作为可输注的可生物降解的MRI剂用于癌症检测的可能性。使用其羟基的化学交换饱和转移（glucoCEST）MRI检测D-葡萄糖信号。使用两种人乳腺癌细胞系MDA-MB-231和MCF-7原位植入裸鼠体内，在体模和体内建立了可行性。还获得了PET和对比增强MRI。两种肿瘤类型在全身性糖输注（轻度高血糖症）期间均表现出显著的glucoCEST信号增强，允许其非侵入性可视化。GlucoCEST显示了不同类型之间的差异，而PET和CE-MRI则没有。讨论了来自肿瘤中血管体积增加的信号贡献，特别是来自酸性细胞外血管外空间（EES）的数据，其中glucoCEST信号预计将由于羟基质子交换的减慢而增强。这一观察结果开辟了使用简单的无毒糖作为造影剂的可能性，通过采用羟基质子作为天然标记，用MRI进行癌症检测。
Modern imaging technologies such as CT, PET, SPECT, and MRI employ contrast agents to visualize the tumor microenvironment, providing information on malignancy and response to treatment. Currently, all clinical imaging agents require chemical labeling, i.e. with iodine (CT), radioisotopes (PET/SPECT), or paramagnetic metals (MRI). The goal was to explore the possibility of using simple D-glucose as an infusable biodegradable MRI agent for cancer detection. D-glucose signals were detected using chemical exchange saturation transfer (glucoCEST) MRI of its hydroxyl groups. Feasibility was established in phantoms as well as in vivo using two human breast cancer cell lines, MDA-MB-231 and MCF-7, implanted orthotopically in nude mice. PET and contrast-enhanced MRI were also acquired. Both tumor types exhibited significant glucoCEST signal enhancement during systemic sugar infusion (mild hyperglycemia), allowing their noninvasive visualization. GlucoCEST showed differences between types, while PET and CE-MRI did not. Data are discussed in terms of signal contributions from the increased vascular volume in tumors and especially from the acidic extracellular extravascular space (EES), where glucoCEST signal is expected to be enhanced due to a slow-down of hydroxyl proton exchange. This observation opens up the possibility for using simple non-toxic sugars as contrast agents for cancer detection with MRI by employing hydroxyl protons as a natural label.
登录
查看更多内容
DOI：
10.1073/pnas.0804224105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Li, Xin;Huang, Wei;Springer, Charles S., Jr.
通讯作者：
Springer, Charles S., Jr.
影响因子：
3.3
作者：
Jones, Craig K.;Polders, Daniel;Hua, Jun;Zhu, He;Hoogduin, Hans J.;Zhou, Jinyuan;Luijten, Peter;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.
影响因子：
4.4
作者：
Kawashima, Miho;Katada, Yoshiaki;Nozaki, Miwako
通讯作者：
Nozaki, Miwako
影响因子：
15
作者：
Goffeney, N;Bulte, JWM;van Zijl, PCM
通讯作者：
van Zijl, PCM
影响因子：
3.3
作者：
Kim M;Gillen J;Landman BA;Zhou J;van Zijl PC
通讯作者：
van Zijl PC