A longitudinal study of health related quality of life and utility measures in patients with advanced breast cancer
A longitudinal study of health related quality of life and utility measures in patients with advanced breast cancer
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DOI：
10.1023/a:1013193007095
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发表时间：
2001-01-01
影响因子：
3.5
通讯作者：
Campbell, AV
中科院分区：
文献类型：
--
作者：
Perez, DJ;Williams, SM;Campbell, AV
健康相关生活质量(HRQOL)测量现在被认为是癌症姑息治疗疗效的指标。效用指标也可能提供有价值的信息，但它们的应用频率较低。为了评估时间权衡(TTO)效用测量的应用及其与Spitzer单量表和生活质量指数(QLI)的一致性，对38名晚期有症状乳腺癌患者进行了为期12个月的研究。QLI与TTO的相关系数为0.54，单刻度与TTO的相关系数为0.62。使用广义估计方程，TTO评分与QLI和Uniscale评分的回归在基线时显着。在纵向分析中，结果仅对QLI有显着意义。虽然所有参与者都完成了HRQOL测量，但只有24人(63%)准备交换时间。其余14人(32%)表示，他们感觉太好了，无法交易。在整个研究过程中，那些准备交换时间的人的平均HRQOL得分明显低于那些感觉太好而不能交换的人，以及那些对治疗反应较差的肿瘤患者。在这项初步研究中，效用和HRQOL得分在整个12个月的研究期间总体上是有利的，并显示出中等到中等的一致性。需要在更大的患者群体中进行进一步的研究，以更好地确定效用和HRQOL测量之间的关系。
Health related quality of life (HRQOL) measures are now accepted as indicators of efficacy in the palliative treatment of cancer. Utility measures may also provide valuable information yet they have been applied less frequently. To assess the application of a time trade-off (TTO) utility measure and its concordance with the Spitzer uniscale and quality of life index (QLI) 38 women with advanced, symptomatic breast cancer were studied over a 12 month period. The correlation coefficient for QLI and TTO values was 0.54 and for uniscale and TTO 0.62. Using generalized estimating equations the regression of TTO scores on QLI and uniscale scores was significant at baseline. In longitudinal analyses results were significant only for QLI. Although all participants completed the HRQOL measures only 24 (63%) were prepared to trade time. The remaining 14 (32%) stated they felt too well to trade. Those prepared to trade time recorded significantly worse mean HRQOL scores throughout the study compared to those who felt too well to trade and had tumors which showed a poorer response to therapy. In this preliminary study utility and HRQOL scores were generally favorable throughout the 12 month study period and showed fair to moderate concordance. Further research in larger patient groups is required to better define the relationships between utility and HRQOL measures.