Nickel(II)-Catalyzed Asymmetric Michael Addition of Oxindoles with Modified N,N,O-Tridentate Chiral Phenanthroline Ligands
Nickel(II)-Catalyzed Asymmetric Michael Addition of Oxindoles with Modified N,N,O-Tridentate Chiral Phenanthroline Ligands
复制标题
镍 (II) 催化的羟吲哚与修饰的 N,N,O-三齿手性菲咯啉配体的不对称迈克尔加成
作者：
Naganawa;Y.; Abe;H.; Nishiyama;H.
在Ni（II）催化下，N，N，O-三齿邻菲咯啉配体存在下，N-叔丁氧羰基吲哚衍生物与甲基乙烯基酮发生了不对称Michael加成反应，得到了具有手性全碳季铵盐中心的加成物，其ee值高达87%.
Nickel(II)-catalyzed enantioselective Michael addition ofN-Boc-oxindole derivatives with methyl vinyl ketone was demonstrated to give the corresponding adducts having chiral all-carbon quaternary centers with up to 87% ee in the presence of axially chiral N,N,O-tridentate phenanthroline ligand.